Artificial intelligence is helping health-care providers better assess their patients' discomfort. For years at Orchard Care Homes, a 23 facility dementia-care chain in northern England, Cheryl Baird watched nurses fill out the Abbey Pain Scale, an observational methodology used to evaluate pain in those who can't communicate verbally. Baird, a former nurse who was then the facility's director of quality, describes it as "a tick box exercise where people weren't truly considering pain indicators." As a result, agitated residents were assumed to have behavioral issues, since the scale does not always differentiate well between pain and other forms of suffering or distress. They were often prescribed psychotropic sedatives, while the pain itself went untreated. Then, in January 2021, Orchard Care Homes began a trial of PainChek, a smartphone app that scans a resident's face for microscopic muscle movements and uses artificial intelligence to output an expected pain score.

How do distributed neural circuits drive purposeful movements from the complex musculoskeletal system? This characterization is critical towards not just furthering our understanding of the generation of movement, but, importantly, guiding us towards therapeutic targets for diseases affecting motor control. The neural processes leading to movements have been relatively well posited and understood due to the quantitative nature of the behavioral outputs involved. Classic approaches have largely focused on optimization principles, including limb control, to achieve human-like behavioral trajectories. These largely theoretical models of sensorimotor control can recapitulate observed movement trajectories by hypothesizing the presence of a controller guiding the complex movements. However, these models cannot predict how neuronal populations in each brain region affects the resulting movement and vice-versa. On the other hand, breakneck advances in hardware techniques have led to vast improvements in our ability to record large-scale multi-regional neural data. These recordings have enabled dimensionality reduction and modeling techniques to elucidate the structure in high-dimensional neural activity during different conditions, and relate the neural activity directly to kinematic outcomes. However, these data-driven models typically do not consider the biophysical underpinnings of the musculoskeletal system, and thus fail to elucidate the computational role of neural activity in driving the musculoskeletal system such that the body reaches a desired state.

Health Medicine Researchers successfully heal rats' broken spines A new study paves the way toward developing a treatment for spinal cord injuries. Breakthroughs, discoveries, and DIY tips sent every weekday. There is currently no way to completely reverse the damage and paralysis that results from a spinal cord injury. One of the biggest obstacles is that neurons die and can't regrow across the damage. Now, researchers have developed a biomedical structure that has given impressive functional recovery to lab rats with severed spinal cords.

Focused ultrasound (FUS) therapy is a promising tool for optimally targeted treatment of spinal cord injuries (SCI), offering submillimeter precision to enhance blood flow at injury sites while minimizing impact on surrounding tissues. However, its efficacy is highly sensitive to the placement of the ultrasound source, as the spinal cord's complex geometry and acoustic heterogeneity distort and attenuate the FUS signal. Current approaches rely on computer simulations to solve the governing wave propagation equations and compute patient-specific pressure maps using ultrasound images of the spinal cord anatomy. While accurate, these high-fidelity simulations are computationally intensive, taking up to hours to complete parameter sweeps, which is impractical for real-time surgical decision-making. To address this bottleneck, we propose a convolutional deep operator network (DeepONet) to rapidly predict FUS pressure fields in patient spinal cords. Unlike conventional neural networks, DeepONets are well equipped to approximate the solution operator of the parametric partial differential equations (PDEs) that govern the behavior of FUS waves with varying initial and boundary conditions (i.e., new transducer locations or spinal cord geometries) without requiring extensive simulations. Trained on simulated pressure maps across diverse patient anatomies, this surrogate model achieves real-time predictions with only a 2% loss on the test set, significantly accelerating the modeling of nonlinear physical systems in heterogeneous domains. By facilitating rapid parameter sweeps in surgical settings, this work provides a crucial step toward precise and individualized solutions in neurosurgical treatments.

A New York man who was left paralyzed after a diving accident is starting to regain movement a year after receiving an artificial intelligence-powered implant in his brain. A year ago, Keith Thomas, 46, was only able to move his arms an inch. Today, after the groundbreaking procedure, he is able to extend his arm, grasp a cup and take a drink using only his thoughts and stimulation. He has also regained more sensation in his wrist and arm, allowing him to feel the fur of his family's dog. In 2020, Thomas was living on Long Island and working as a trader on Wall Street when he experienced a diving accident that left him paralyzed from the chest down.

While deep learning has catalyzed breakthroughs across numerous domains, its broader adoption in clinical settings is inhibited by the costly and time-intensive nature of data acquisition and annotation. To further facilitate medical machine learning, we present an ultrasound dataset of 10,223 Brightness-mode (B-mode) images consisting of sagittal slices of porcine spinal cords (N=25) before and after a contusion injury. We additionally benchmark the performance metrics of several state-of-the-art object detection algorithms to localize the site of injury and semantic segmentation models to label the anatomy for comparison and creation of task-specific architectures. Finally, we evaluate the zero-shot generalization capabilities of the segmentation models on human ultrasound spinal cord images to determine whether training on our porcine dataset is sufficient for accurately interpreting human data. Our results show that the YOLOv8 detection model outperforms all evaluated models for injury localization, achieving a mean Average Precision (mAP50-95) score of 0.606. Segmentation metrics indicate that the DeepLabv3 segmentation model achieves the highest accuracy on unseen porcine anatomy, with a Mean Dice score of 0.587, while SAMed achieves the highest Mean Dice score generalizing to human anatomy (0.445). To the best of our knowledge, this is the largest annotated dataset of spinal cord ultrasound images made publicly available to researchers and medical professionals, as well as the first public report of object detection and segmentation architectures to assess anatomical markers in the spinal cord for methodology development and clinical applications.

Mammals can generate autonomous behaviors in various complex environments through the coordination and interaction of activities at different levels of their central nervous system. In this paper, we propose a novel hierarchical learning control framework by mimicking the hierarchical structure of the central nervous system along with their coordination and interaction behaviors. The framework combines the active and passive control systems to improve both the flexibility and reliability of the control system as well as to achieve more diverse autonomous behaviors of robots. Specifically, the framework has a backbone of independent neural network controllers at different levels and takes a three-level dual descending pathway structure, inspired from the functionality of the cerebral cortex, cerebellum, and spinal cord. We comprehensively validated the proposed approach through the simulation as well as the experiment of a hexapod robot in various complex environments, including obstacle crossing and rapid recovery after partial damage. This study reveals the principle that governs the autonomous behavior in the central nervous system and demonstrates the effectiveness of the hierarchical control approach with the salient features of the hierarchical learning control architecture and combination of active and passive control systems.

The ways we communicate are multilayered, and psychologists have devised many kinds of tests to measure our ability to infer meaning and understanding from interactions with each other. AI models are getting better at these tests. New research published has found that some large language models perform as well as, and in some cases better than, humans when presented with tasks designed to test the ability to track people's mental states, known as "theory of mind." This doesn't mean AI systems are actually able to work out how we're feeling. But it does demonstrate that these models are performing better and better in experiments designed to assess abilities that psychologists believe are unique to humans.

A four-legged robot trained with machine learning by EPFL researchers has learned to avoid falls by spontaneously switching between walking, trotting, and pronking – a leaping, arch-backed gait used by animals like springbok and gazelles. With the help of a form of machine learning called deep reinforcement learning (DRL), the EPFL robot notably learned to transition from trotting to pronking to navigate a challenging terrain with gaps ranging from 14-30cm. The study, led by the BioRobotics Laboratory in EPFL's School of Engineering, offers new insights into why and how such gait transitions occur in animals. "Previous research has introduced energy efficiency and musculoskeletal injury avoidance as the two main explanations for gait transitions. More recently, biologists have argued that stability on flat terrain could be more important. But animal and robotic experiments have shown that these hypotheses are not always valid, especially on uneven ground," says PhD student Milad Shafiee, first author on a paper published in Nature Communications.

Animals possess a remarkable ability to navigate challenging terrains, achieved through the interplay of various pathways between the brain, central pattern generators (CPGs) in the spinal cord, and musculoskeletal system. Traditional bioinspired control frameworks often rely on a singular control policy that models both higher (supraspinal) and spinal cord functions. In this work, we build upon our previous research by introducing two distinct neural networks: one tasked with modulating the frequency and amplitude of CPGs to generate the basic locomotor rhythm (referred to as the spinal policy, SCP), and the other responsible for receiving environmental perception data and directly modulating the rhythmic output from the SCP to execute precise movements on challenging terrains (referred to as the descending modulation policy). This division of labor more closely mimics the hierarchical locomotor control systems observed in legged animals, thereby enhancing the robot's ability to navigate various uneven surfaces, including steps, high obstacles, and terrains with gaps. Additionally, we investigate the impact of sensorimotor delays within our framework, validating several biological assumptions about animal locomotion systems. Specifically, we demonstrate that spinal circuits play a crucial role in generating the basic locomotor rhythm, while descending pathways are essential for enabling appropriate gait modifications to accommodate uneven terrain. Notably, our findings also reveal that the multi-layered control inherent in animals exhibits remarkable robustness against time delays. Through these investigations, this paper contributes to a deeper understanding of the fundamental principles of interplay between spinal and supraspinal mechanisms in biological locomotion. It also supports the development of locomotion controllers in parallel to biological structures which are ...